Alpha-2-Macroglobulin (A2M)

Pain Management & Anesthesiology located in Augusta, Austell, Brookhaven, Camp Creek, Piedmont/Atlanta, Sandy Springs, Canton, Carrollton, Cartersville, Conyers, Covington, Dallas, Douglasville, Jasper, Johns Creek, Suwanne, Lawrenceville, Marietta, Peachtree City, Roswell, and Woodstock, GA


Revitalize Your Life with A2M Therapy at Alliance Spine and Pain


Are you searching for a groundbreaking solution to alleviate joint pain and inflammation? Alliance Spine and Pain is proud to introduce Alpha-2-Macroglobulin (A2M) Therapy – a cutting-edge treatment that targets the root cause of joint degeneration, offering you a path to renewed mobility and well-being.

Alpha-2-Macroglobulin Q&A

What is A2M?

Alpha-2-Macroglobulin (A2M) is a naturally occurring protein in the body that plays a crucial role in inhibiting enzymes responsible for joint degradation. A2M Therapy involves isolating and concentrating this powerful protein to deliver targeted relief for joint-related pain and inflammation.

How Does A2M Work?

A2M Therapy is a minimally invasive procedure where the concentrated A2M solution is injected directly into the affected joint. This powerful protein acts as a natural inhibitor, neutralizing the destructive enzymes that contribute to joint degeneration. By halting the degenerative process, A2M Therapy promotes joint healing, reduces inflammation, and provides lasting relief.

Why Choose A2M at Alliance Spine and Pain?

  1. Precision Joint Relief:

    A2M Therapy specifically targets the underlying causes of joint pain, offering a precise and effective solution for long-term relief.

  2. Non-Surgical Alternative: 

    Say goodbye to invasive procedures. A2M Therapy is a non-surgical approach that harnesses the body's natural healing abilities without the need for extensive recovery periods.

  3. Expert Guidance with Dr. Richard Gayles: 

    Schedule a consultation with Dr. Gayles, a trusted expert in pain management, to determine if A2M Therapy is the right fit for your unique needs. Benefit from personalized care and cutting-edge treatments.

  4. Comprehensive Approach to Joint Health: 

    A2M Therapy at Alliance Spine and Pain addresses not just the symptoms but the root causes of joint degeneration, promoting overall joint health and functionality.

Ready to Rediscover Freedom of Movement?

Take the first step towards a life free from joint pain and inflammation. Schedule a consultation with Dr. Richard Gayles at Alliance Spine and Pain to explore the transformative benefits of A2M Therapy. Reclaim your mobility and embrace a future filled with vitality.


Your journey to joint health begins here – contact us now to book your consultation and embark on the path to a pain-free, active lifestyle. Your revitalized future awaits.

How much does it cost?

Insurance does not cover regenerative services at this time.  The cost will be $1,500.00 per treatment site.

Pre and Post Instructions for Stem Cell Therapy Treatment

Welcome to your journey with stem cell therapy, an innovative approach to healing and wellness. To ensure the best possible outcomes from your treatment, it is crucial to follow these pre and post-treatment instructions carefully.

Pre-Treatment Instructions

  1. Medical Review and Patient Portal:

    • Ensure all your medical history have been uploaded into your portal and current medications.

    • Discuss any allergies, past surgeries, and your overall health condition with Dr. Gayles.

    • No recent smoking history within 30 days of procedure.

  2. Medication Adjustments:

    • Some medications, especially anti-inflammatory drugs or vitamins, may need to be stopped a few 7 days before the treatment. Please consult with Dr. Gayles for specific instructions.

    • Avoid NSAIDS for 6-8 weeks post procedure

    • Avoid Steroid use 8 weeks post procedure

  3. Diet and Hydration:

    • Stay hydrated and maintain a healthy diet leading up to your treatment.

    • Avoid alcohol and reduce caffeine intake 24 hours before the procedure.

  4. Physical Preparation:

    • Get plenty of rest the night before.

    • Wear comfortable, loose-fitting clothing on the day of your treatment.

  5. Arrange Transportation if needed:

    • Plan for someone to drive you home after the procedure, as you may experience temporary discomfort or drowsiness. This only applies to BMAC and Adipose Derived Extractions.

Post-Treatment Instructions

  1. Activity Restriction:

    • Avoid strenuous activities and heavy lifting for four  weeks after the treatment.

    • PT will begin two weeks post procedure

    • Gentle walks are encouraged to promote circulation.

  2. Pain Management:

    • You may experience mild discomfort or swelling at the injection site. Use ice packs and prescribed pain relievers if necessary.

  3. Hydration and Diet:

    • Continue to drink plenty of water.

    • Eat an anti-inflammatory diet rich in antioxidants to support healing.

    • Avoid alcohol for at least 4-6 weeks post-procedure

    • Nutritional supplement to be recommended by MD

  4. Follow-Up Appointments:

    • Attend all scheduled follow-up appointments to monitor your progress.

    • Keep a record of any changes or improvements you notice.

  5. Lifestyle Considerations:

    • Avoid smoking and limit alcohol consumption as these can hinder the healing process.

    • Obtain a minimum of 8 hours of sleep post procedure post procedure


Every individual’s response to stem cell therapy can vary. It is important to maintain open communication with your Concierge and report any concerns or unusual symptoms immediately.


By adhering to these guidelines, you are contributing significantly to the success of your stem cell therapy. We are committed to supporting you throughout this journey towards improved health and wellness.


For any questions or additional guidance, please do not hesitate to contact your Concierge.